Development of peptide nucleic acid probes for detection of the HER2 oncogene.
Peptide nucleic acids (PNAs) have gained much interest as molecular recognition tools in biology, medicine and chemistry.This is due to high hybridization efficiency to complimentary oligonucleotides and stability of the duplexes with RNA or DNA.We have synthesized 15/16-mer PNA probes to detect the HER2 mRNA.The performance of these probes to dete